Tacrolimus Topical For Dogs

Topical route ointment long term safety of topical calcineurin inhibitors has not been established and rare cases of malignancy eg skin and lymphoma have been reported in patients treated with topical calcineurin inhibitors including tacrolimus ointment.

Tacrolimus topical for dogs.

This material is provided for educational purposes only and is not intended for medical advice diagnosis or treatment. Protopic ointment is a topical medication. Can vet j 41 623 627 pubmed. The usual concentration for dogs is 0 1 percent tacrolimus although 0 03 percent is available.

Plosker g l foster g h 2000 tacrolimus a further update of its pharmacology and therapeutic use in the management of organ transplantation. Tacrolimus is very well tolerated in the ophthalmic treatment of kcs. This study was a two phase randomized controlled masked clinical trial. Animal studies suggest that prolonged use of tacrolimus is associated with an increased risk of conditions such as skin malignancies lymphomas and infections.

In dogs with refractory dry eye 37 5 of eyes treated with sirolimus exhibited increased tear production 4 mm min after 6 weeks of treatment compared to 20 of eyes receiving tacrolimus p 0 433. Only topical use of tacrolimus is recommended currently. The veterinary term for dry eye is keratoconjunctivitis sicca or kcs. Tacrolimus is most commonly prescribed by veterinarians to treat dogs and cats that have been diagnosed with keratoconjunctivitis sicca.

Gi symptoms may be encountered from ingestion of the topical ointment licking. Tacrolimus sold under the brand names protopic and prograf among others is an immunosuppressive drug it is used after allogeneic organ transplant to lower the risk of organ rejection and also as a topical medication in the treatment of t cell mediated diseases such as eczema and psoriasis it also used for severe refractory uveitis after bone marrow transplants exacerbations of minimal. One normal dog experienced topical irritation to both sirolimus and vehicle treatment. Tacrolimus has anti inflammatory immunosuppressive and immunomodulatory properties that make it suitable for a variety of treatments in the veterinary field.

Data sources include ibm watson micromedex updated 2 sep 2020 cerner multum updated 1 sep 2020 wolters kluwer updated. The purpose of this paper was to determine the efficacy and safety of topical tacrolimus compared to cyclosporine for treating keratoconjunctivitis sicca kcs in dogs. Tacrolimus is a calcineuron inhibitor that also can be used to treat dermatologic problems such as superficial keratitis miliary dermatitis and atopic dermatitis. Tacrolimus generally is well tolerated for the localized topical treatment of dermatologic problems.

Misseghers b s binnington a g mathews k a 2000 clinical observations of the treatment of canine perianal fistulas with topical tacrolimus in 10 dogs. Tacrolimus is one of a group of relatively new drugs used to treat dry eye in dogs and cats. Phase 1 evaluated ophthalmic 0 03 tacrolimus in normal dogs.